In 1990 Vedder formed the band Pearl Jam with guitarists Mike McReady and Stone Gossard, bassist Jeff Ament, and drummer Dave Krusen. Krusen has since been replaced by Soundgarden's Matt Cameron. The original name of the band was Mookie Blaylock, after the University of Oklahoma basketball player, whose jersey number, 10, was made the tile of the their first album. They were forced to change the band's name after signing with Epic , but kept the album title. The album, which would produce 1990s classics like “Alive”, the anthem “Evenflow”, and the quintessential angst-ridden teen theme song: “Jeremy”, would link the band's name with Seattle grunge for all time. Ten would go on to be certified 13x platinum.
Despite having a spat during the height of Ten's success, Nirvana’s Kurt Cobain and Eddie Vedder would be on good terms by the time Cobain died in 1994. Cobain had claimed that Pearl Jam was not truly alternative. Throughout the 1990s, the band would take several anti-commercial ideological stances, including not making videos for several of their most popular songs, and boycotting Ticketmaster. They would also be a backing band for one of their major influences: Neil Young.
In addition to the his musical contributions to the band, Vedder is an artist, creating works under the names Jerome Turner and Wes C. Addle. As a solo performer he has won a Golden Globe Award and a Grammy Award for his song “Guaranteed”, which was featured on the soundtrack of the movie Into the Wild.